This is a list of events that occurred in the 2300s and beyond:
- (Possible Future): According to Galen, Emperor Dius Vintari decides that his plan to bring the Centauri Republic back to its former glory requires the elimination of Earth and so launches a devastating assault with a thousand vast war machines, each of them armed with terrible engines of destruction.
- On the 100th Anniversary of the Interstellar Alliance, Barbara Tashaki and Exeter analyze the past 100 years of its operation. Delenn unexpectedly arrives and informs them that John Sheridan "was a good man". 
- January 2
- On the 500th Anniversary of the founding of the Interstellar Alliance, Daniel, at the behest of Politdivision Central creates holographic simulations of John Sheridan, Delenn, Stephen Franklin, and Michael Garibaldi. His intent is to create a series of reverse-correct infospeak vids that de-construct the historical figures revered by the prole sector and supports current changes in Earth policy. The Simulation of Garibaldi hacks the computer system an broadcasts his conversation with Daniel, alerting the ISA loyalist faction to the separatist plans to simultaneously strike at the outer-world colonies and the opposing nations on Earth. The loyalists launch an immediate pre-emptive strike, setting in motion the Second Earth Alliance Civil War and the Great Burn.
- 1000th Anniversary of the Interstellar Alliance.
- Michael and Alwyn Macomber discuss the key players in the Army of Light from 2261.
- Lyta Alexander claims humanity will be ready to travel to the Vorlon homeworld when humanity has "earned the right to go there, a million years from now."
- Jason Ironheart says he'd see Sinclair again in "a million years."
- Earth is destroyed when Sol goes supernova. By this time, humans have evolved into Vorlon-like energy beings and may be living on the former Vorlon homeworld.
|Before the Third Age:||20th Century and earlier 21st Century 22nd Century 2200s 2210s 2220s 2230s 2240s|
|2250s:||2250 2251 2252 2253 2254 2255 2256 2257 2258 2259|
|2260s:||2260 2261 2262 2263 2264 2265 2266 2267 2268 2269|
|2270s onwards:||2270s 2280s 2290s 2300s and beyond|