Lewis Arquette (b. December 14, 1935 – d. February 10, 2001) was an American film actor, writer and producer.

He was a part of the famous Arquette family and the father of actors Patricia, Alexis, Rosanna, David and Richmond Arquette. He was the father-in-law of actress Courteney Cox and actor Thomas Jane and the former father-in-law of actor Nicolas Cage.

Arquette died in Los Angeles, California in 2001, due to congestive heart failure.