The Telepath War was a conflict with non-telepathic humans and rogue human telepaths on one side and the Psi Corps on the other. Official Earth Alliance media called it the Telepath Crisis, in an attempt to downplay its severity.
One contributing factor to the beginning of this war was the creation of a colony of telepaths on Babylon 5 by Sheridan and Delenn. Sheridan later described it as the worst mistake of his career. The colony was created in an attempt to control and influence telepaths, but they turned on him. 
During the war, the Psi Corps attempted to take over the Earth Alliance. The Interstellar Alliance entered the fight to help on the side of the mundanes and rogue telepaths. The climax of the war came when Psi Corps Headquarters was destroyed, resulting in the deaths of hundreds of Alfred Bester's men. The telepath resistance leader Lyta Alexander and the disgraced Minbari Ranger Lennier were also amongst the casualties.
- The exact dates of the war are not given, but it was "recently" over by the time of "A Call to Arms," set in December 2266.